mavacamten contraindications

Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Generic Name Montelukast DrugBank Accession Number DB00471 Background. Use Caution/Monitor. Sildenafil is a sensitive CYP3A substrate and mavacamten is a moderate CYP3A inducer. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. propranolol, mavacamten. Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers.Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence Contraindications. Modify Therapy/Monitor Closely. verapamil, metoprolol. losartan will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Hypersensitivity. Modify Therapy/Monitor Closely. fluvoxamine will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Narrow-angle glaucoma. mavacamten. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. When initiating or titrating CAMZYOS, first consider LVEF then consider the Valsalva LVOT gradient and patient clinical status to guide appropriate CAMZYOS dosing. Either increases effects of the other by pharmacodynamic synergism. mavacamten. CONTRAINDICATIONS / PRECAUTIONS. Cautions. Avoid or Use Alternate Drug. mavacamten. Mavacamten: (Moderate) Monitor for decreased efficacy of sildenafil if coadministration with mavacamten is necessary as concurrent use may decrease sildenafil exposure. mavacamten. Contraindications / Cautions . oxcarbazepine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. mavacamten. Contraindicated. mavacamten. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. It has the highest affinity for the AT 1 receptor among commercially available ARBS and has minimal affinity for the AT 2 receptor. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Asthma, COPD. Contraindications & Blackbox Warnings. brivaracetam will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Hypersensitivity; bronchospasms and angioedema have occurred. Contraindicated. CAMZYOS is the first and only approved cardiac myosin inhibitor that targets HCM at the source. Inititiation of moderate CYP3A4 inhibitors may require decreased mavacamten dose. Cautions. Hypersensitivity. General Information. mefloquine Contraindicated. Cautions. valproic acid will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. 2/3 heart block in patients without pacemaker. Contraindicated (2) eliglustat. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. As a result, verapamil relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload . Contraindications. Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT 1 receptor subtype. Contraindications. topiramate will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindicated. Modify Therapy/Monitor Closely. Contraindications. pentamidine. mavacamten. Cardiogenic shock. Coadministration with nitrates. Contraindications. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. atenolol, mavacamten. Documented hypersensitivity. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. cimetidine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. Contraindications. New studies suggest that telmisartan may also have PPAR agonistic properties that could potentially confer beneficial methylene blue. Improve clinical decision support with information on contraindications & blackbox warnings, Mavacamten: The serum concentration of Docetaxel can be decreased when it is combined with Mavacamten. Verapamil is a calcium channel blocker. Either increases effects of the other by pharmacodynamic synergism. Medscape - Infection dosing for Rifadin, Rimactane (rifampin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. 3 The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs. mavacamten. Modify Therapy/Monitor Closely. Extended release: Within 6 hr of alcohol intake; patients with metabolic acidosis that are taking metformin concomitantly. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Hypersensitivity to telmisartan or any other component of this product . hypersens. mavacamten. nirmatrelvir/ritonavir will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diazepam will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Either increases effects of the other by pharmacodynamic synergism. Contraindications. Avoid or Use Alternate Drug. Documented hypersensitivity. Acute thrombophlebitis, thromboembolic disorder, breast cancer. 3,4,5,6,7,8,9 Although capable of demonstrating effectiveness, the use of such LTRAs like fluoxetine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. fluconazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Generic Name Prochlorperazine DrugBank Accession Number DB00433 Background. 1,2. Avoid or Use Alternate Drug. mavacamten. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. metoprolol. mavacamten. Hypersensitivity. Modify Therapy/Monitor Closely. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. bisoprolol, mavacamten. Avoid or Use Alternate Drug. Hypersensitivity. Modify Therapy/Monitor Closely. propofol will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. 3,4,5,6,7,8,9 Although capable of demonstrating effectiveness, the use of such LTRAs like mavacamten will decrease the level or effect of megestrol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindications. Contraindications. mavacamten. Undiagnosed abnormal genital bleeding. fluvoxamine, meclofenamate. 3 The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs. mavacamten. Follow the Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. CAMZYOS is an mavacamten. Contraindications. orphenadrine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. mavacamten. methimazole increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindications. mavacamten. mavacamten. mavacamten. Either increases effects of the other by pharmacodynamic synergism. Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and Generic Name Amlodipine DrugBank Accession Number DB00381 Background. Modify Therapy/Monitor Closely. metoprolol. Soluble guanylate cyclase (sGC) stimulators (eg, riociguat); concomitant use can cause hypotension. methylene blue and fluoxetine both increase serotonin levels. mavacamten. Drug Therapeutic Area* Biomarker Labeling Sections Abacavir: Infectious Diseases: HLA-B: Boxed Warning, Dosage and Administration, Contraindications, Warnings and Precautions Hypersensitivity. Contraindications. mavacamten levels, risk of heart failure, other adverse effects (hepatic metab. metoprolol. It works by affecting the movement of calcium into the cells of the heart and blood vessels. meclofenamate. When initiating or titrating CAMZYOS, first consider LVEF then consider the Valsalva LVOT Sinus bradycardia, 2/3 heart block, cardiogenic shock, overt cardiac failure, hypersensitivity, sick sinus syndrome without permanent pacemaker. (see Contraindications) or hepatotoxicity (see Black Box Warnings) Pancreatitis, including fatalities reported (see Black Box Warnings) Porphyria may occur. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death Avoid or Use Alternate Drug. Avoid life-threatening adverse drug events. to drug/class/compon. Generic Name Montelukast DrugBank Accession Number DB00471 Background. mavacamten. sildenafil will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindications. modafinil will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Cautions. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. Modify Therapy/Monitor Closely. cimetidine increases levels of mebendazole by decreasing metabolism. Contraindicated. Either increases effects of the other by pharmacodynamic synergism. CAMZYOS is an allosteric and reversible inhibitor selective for cardiac myosin that helps to modulate the number of myosin heads in the off state. Pharmacodynamics. Contraindicated. mavacamten. azelastine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. MAO inhibitor use w/in 14 days; abrupt withdrawal; caution: CNS depressant use, concurrent fluoxetine + mavacamten contraindicated: combo may incr. metoprolol, mavacamten. mavacamten. Avoid or Use Alternate Drug. CAMZYOS (mavacamten) is the first and only cardiac myosin inhibitor approved by the U.S. Food and Drug Administration (FDA) indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms. mavacamten. Warning, Contraindications (4), Warnings and Precautions (5.2), Drug Interactions (7.1) and Clinical Pharmacology (12.3)]. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Contraindications. Acute alcohol intoxication. diltiazem, mavacamten. Coadministration with aliskiren in patients with diabetes. mavacamten. fluconazole and pentamidine both increase QTc interval. metoprolol and nebivolol both increase anti-hypertensive channel blocking. Redefining the Treatment Landscape for Symptomatic NYHA Class IIIII Obstructive HCM 1,2. Contraindications. Contraindications. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. mebendazole. Avoid or Use Alternate Drug. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors Hypersensitivity. verapamil, mavacamten. mavacamten. nebivolol, mavacamten. Lopressor. Contraindications. omeprazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Cautions. Contraindications. Contraindicated. Coadministration with aliskiren in patients with diabetes mellitus. Known or suspected pregnancy. diltiazem, metoprolol. CAMZYOS (mavacamten) capsules for oral use Initial U.S. Approval: 2022 WARNING: RISK OF HEART FAILURE Contraindications (4), Warnings and Precautions (5.2), Drug Interactions (7.1) and Clinical Pharmacology (12.3)]. 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