Many drugs can do this. But its possible that some of Xgevas side effects might last longer. Do not flush down a toilet or pour down a drain unless you are told to do so. MedicineNet does not provide medical advice, diagnosis or treatment. There are no adequate and well-controlled studies on denosumab use in pregnant women. Yikes! Drink at least 2to 3 quarts of fluid every 24 hours, unless you are instructed Xgeva may not be right for you if you have certain medical conditions or other factors that affect your health. This drug may cause jawbone problems. It is important not to become pregnant or father a child while you're having treatment. Some people find it easiest to take them first thing in the morning and wait at least an hour before eating anything or having any milk. Vitamin D helps the body absorb calcium. What is denosumab, and what is it used for? Any new or strange groin, hip, or thigh pain. Signs of low calcium levels like muscle cramps or spasms, numbness and tingling, or seizures. Follow all instructions closely. The most common side effects of this drug involve pain located in the back, feet, hands, muscles, or bones. your general health or other health problems, and the type of cancer or condition Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Learn about the types, causes, and treatment of bone cancer. Osteonecrosis (pronounced oss-tee-oh-neh-kro-sis) means death of bone tissue. I have noticed that my fingernails and hair are growing faster. Treatment of giant cell tumor of the bone. You'll have regular blood tests to check how well your kidneys are working. Denosumab side effects are often predictable in terms of their onset, duration and Do not share your drugs with others and do not take anyone elses drugs. elect to use this same drug for other problems if they believe it might be helpful. Most of its side effects are mild, but its possible to have serious side effects. Has anyone experienced neuropathy occurring after a Prolia injection? If you have questions about side effects, call your doctor. Tell your doctor if you already have problems with your food pipe (oesophagus) or if you develop new symptoms such as pain or difficulty swallowing. If you may become pregnant, you must use birth control while taking this drug and for some time after the last dose. Patients or their physicians should call 1-800-77-AMGEN (1-800-772-6436) to enroll. Common side effects may include: bladder infection (painful or difficult urination); Before startingdenosumab treatment, make sure you tell your doctor about any These may occur with some types of bisphosphonates but are usually mild. Below is information about using Xgeva during pregnancy or while breastfeeding. Acetaminophen may help relieve discomfort from fever, headache and generalized aches such as calcium from bone fluid into the blood, is called "bone resorption". Sarfaroj Khan, BHMS, PGD Health Operations, Women receiving aromatase inhibitor therapy for, Prevention of skeletal-related events in patients with. Denosumab injection may cause side effects. Ask your doctor how long to use birth control. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. pain), Fatigue and extreme tiredness (unable to perform self-care activities). If treatment with this drug is stopped, skipped, or delayed, the chance of a broken bone is raised. Denosumab is a lab-made human monoclonal immunoglobulin G2 (IgG2) antibody that specifically blocks the activity of the primary signaling protein involved in the resorption of bone tissue, preventing bone loss. If your doctor confirms that you had a serious allergic reaction to Xgeva, they may have you switch to a different treatment. Denosumab is available in two brands, Prolia and Xgeva, and the two brands have different dosage strengths and are used for different indications. Denosumab can cause pain in the bones and joints. growth factors that may cause growth of tumors. High calcium levels have happened after this drug was stopped in people whose bones were still growing and people with giant cell bone tumor. They may perform tests to make sure your back pain isnt a symptom of a serious side effect. Receptor activator of nuclear factor kappa-B ligand (RANKL) is a type of protein WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. or surgery to fix or stabilize an affected bone. To understand how bisphosphonates work, it helps to know a bit about normal bone activity. If youd like to notify the FDA about a side effect youve had with Xgeva, visit MedWatch. [1] [2] Denosumab is contraindicated in people with low blood calcium levels. The following are common (occurring in greater than 30%) side effects for patients taking denosumab: Fatigue Muscle weakness Decreased levels of phosphorus in your blood ( hypophosphatemia) Nausea These are less common side effects (occurring in 10-29%) for patients receiving denosumab: Diarrhea Shortness of breath Some drugs may have another patient information leaflet. You should have a dental check up before you start treatment. inhibiting RANKL we may be able to decrease bone resorption and therefore decrease You will be checked regularly by your doctor while you are taking denosumab, to A very rare side effect with denosumab is osteonecrosis of the jaw (ONJ). Inform your physician immediately if you become pregnant or suspect pregnancy while on denosumab therapy. serum CTX decreases more than 80% one week after injection and at 12 months BMD increases 1 to 7% according to the skeletal site [1]McClung, M.R., et al., Denosumab in postmenopausal women with low bone mineral density. The National Women's Health Network suggests women try other FDA-approved osteoporosis medications prior to trying Prolia. Adverse Reactions. If hypersensitivity reactions develop, institute appropriate treatment and discontinue denosumab permanently. But its not clear whether this side effect occurred in studies. This presents with jaw pain. Sometimes, blood calcium levels have stayed low for weeks or months after use of this drug. Take good care of your teeth. Accessed June 2017, Prostate cancer: diagnosis and management, National Institute for Health and Care Excellence (NICE), 2019, Early and locally advanced breast cancer: diagnosis and management, National Institute for Health and Care Excellence (NICE), 2018, National Institute for Health and Care Excellence (NICE), 2016. If your back pain is mild, your doctor may suggest that you take drugs such as ibuprofen (Advil, Motrin) or acetaminophen (Tylenol) to ease your pain. Muscle stiffness, twitching, spasms, or cramps (signs of low blood calcium). There may be drug take-back programs in your area. Bone and teeth growth may also be affected. Sub-group analysis of female subjects showed that the risk of new or worsening vertebral fracture at 24 months was reduced by 63.2% in the denosumab group compared with . It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. In They can suggest ways to ease your symptoms. Nausea that interferes with eating and is not relieved by medications prescribed About Cancer generously supported by Dangoor Education since 2010. Denosumab is approved to prevent: Broken bones and other bone problems caused by multiple myeloma or by solid tumors that have metastasized (spread) to bone. deprivation therapy for non-metastatic prostate cancer. If you are using another drug that has the same drug in it. It can also cause some pain in the muscles. Are there any symptoms of this side effect I should watch for? Learn more about the many myelofibrosis clinical trials, including jak2 clinical trials, how to participate, risks, success rates, and more. Do not take aspirin or products containing aspirin unless your Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Don't take Xgeva (denosumab) if you're pregnant. Tiredness and low energy levels These may occur with some types of bisphosphonates but are usually mild. It should be safe to drink alcohol while using Xgeva. What are the side effects of Denosumab (Prolia) (Subcutaneous)? Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. 2005-2022 Healthline Media a Red Ventures Company. Prolia Side Effects: The New Study on Prolia Is Really Scary The new research concerns the cases of nine women who had taken Prolia and then stopped the drug. Call freephone 9 to 5 Monday to Friday or email us, General side effects of bisphosphonates and denosumab, Read about cancer and low calcium levels here, Read about bisphosphonates and jaw problems, Find out more about side effects of cancer drugs and how to cope with them. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care providers examination and assessment of a patients specific and unique circumstances. Xgeva can cause certain fractures during treatment and after you stop using it. A dental examination with appropriate preventative dentistry should be considered treat giant cell tumors (a mass or lump of cancer tissue that contains a large number of cancer cells) in adults and some children, changes in the level of calcium in your blood, which may be, teeth that are loose, infected, or that ache, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dosage of the drug you were using when you had the side effect, how soon after starting that dosage you experienced it, any other information you feel is important. otherwise, as it is important to avoid becoming dehydrated. You will also be given a pregnancy test before starting the treatment. This is not a complete list of denosumab side effects. Monday to Friday, 8 a.m. to 6 p.m. (Eastern time), Monday to Friday, 9 a.m. to 5 p.m. (Eastern time). Many bone loss conditions are caused when the bone loss from osteoclast activity is more rapid than the rate of new bone tissue growth from osteoblasts. The information contained Denosumab prevents RANKL from binding to RANK receptors in the osteoclasts and activating the bone resorption process. excess air or gas in the stomach or bowels feeling of constant movement of self or surroundings feeling of fullness heartburn lack or loss of strength passing gas redness, pain, itching, burning, swelling, or a lump under your skin where the shot was given sensation of spinning trouble sleeping upper abdominal or stomach pain It may not be safe to use Xgeva while pregnant. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctors recommendation. This typically happens around 12 years of age. Drug Class: Antineoplastics, Monoclonal Antibody;Monoclonal Antibodies, Endocrine. We'll teach you all about the various types, how they're diagnosed, and treatments. Because low phosphate is a relatively common side effect of Xgeva, your doctor will monitor your levels throughout your treatment. For more information on drug interactions, visit the RxList Drug Interaction Checker. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators . The chance of having more than 1 broken bone in the spine is raised if you have ever had a broken bone in your spine. You will have blood tests to check the levels of calcium and other minerals such as potassium and magnesium. And dont stop using Xgeva unless your doctor recommends it. It can even be life threatening. Do not start, stop, or change the dose of any drug without checking with your doctor. Bisphosphonates dont usually cause too many side effects. Do not use both Xgeva and Prolia at the same time. Human studies havent looked at whether the drug passes into breast milk or what effects it could have on a breastfed child. Tell your doctor if you have any side effect that bothers you or that does not go away. Rare side effects include severe infusion reactions, hypersensitivity reactions, anaphylaxis, hypocalcemia, osteonecrosis of the jaw and atypical femoral fractures. Taking painkillers like paracetamol can help. referring to the generic drug name denosumab. These side effects can vary, depending on the condition the drug is being used to treat. Xgeva may cause mild side effects other than the ones listed above. Healthline Media does not provide medical advice, diagnosis, or treatment. Specifically, Treatment to increase bone mass in men at high risk for fracture receiving androgen If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. aromatase inhibitor therapy for breast cancer. It is used to treat soft, brittle bones (osteoporosis). It is not known whether denosumab is excreted into human milk. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. And dental problems are often early warning signs of this side effect. For more information about Xgeva, including details about its uses, see this in-depth article on the drug. related events) that can result from this bone breakdown are bone pain, fractures, If you have bone problems caused by certain cancers, your doctor might suggest Xgeva (denosumab) as a treatment option for you. doctor permits this. This drug may lower blood calcium levels. Constipation, diarrhea, stomach pain, upset stomach, throwing up, or decreased appetite. If your doctor confirms that you had a mild allergic reaction to Xgeva, theyll decide if you should continue using it. The exact causes are not known. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. skin. 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