The most common side effects of Prolia in women who are being treated for osteoporosis after menopause are: The most common side effects of Prolia in men with osteoporosis are: The most common side effects of Prolia in patients with glucocorticoid-induced osteoporosis are: The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are: Tell your doctor if you have any side effect that bothers you or that does not go away. Medication Guide. 4 P. 6. you should know that denosumab injection may cause osteonecrosis of the jaw (ONJ, a serious condition of the jaw bone), especially if you have dental surgery or treatment while you are receiving this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. You will need to have a negative pregnancy test before starting treatment with denosumab injection. It should only be used if other treatment methods have failed or by post-menopausal women who have severe osteoporosis. What is the most important information I should know about Prolia? Tell your dentist that you are receiving Prolia before you have dental work. Read it with care. Prolia (denosumab) and Boniva (ibandronate) are used to prevent and treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. This is not a list of all drugs or health problems that interact with denosumab injection (prolia). If you think there has been an overdose, call your poison control center or get medical care right away. Know the medicines you take. This medicine comes with an extra patient fact sheet called a Medication Guide. Prolia is an injection that will be given to you by a healthcare professional. Prolia is also used to help prevent bone fractures in people with breast or prostate cancer who are taking certain medications. The typical injection dosage is one syringe every 6 months. Denosumab injection may also cause broken bones to heal slowly and may impair bone growth and prevent teeth from coming in properly in children. Sometimes, blood calcium However, you should not flush this medication down the toilet. in your skin, lower stomach area (abdomen), bladder, or ear may happen. Increase bone mass in men with osteoporosis who are at high risk for fracture. have happened in people who take Prolia. The information shared above about the question, 1.Prolia (denosumab) | Postmenopausal Osteoporosis Treatment, 2.Prolia (Denosumab Injection): Uses, Dosage, Side Effects RxList, 3.Prolia (Injection) Uses, Dosage & Side Effects Drugs.com, 4.Prolia: Side Effects, Alternatives, How Its Administered, and More, 5.Prolia injection (denosumab): Side effects, cost, and more, 6.Prolia side effects: What you should know Medical News Today, 8.Prolia Subcutaneous: Uses, Side Effects, Interactions WebMD, 9.Denosumab (Subcutaneous Route) Description and Brand Names, TOP 9 what is prolia injection used for BEST and NEWEST, TOP 9 what is prolapsed bladder BEST and NEWEST, TOP 8 what is prolactin level BEST and NEWEST, TOP 9 what is projector audio BEST and NEWEST, TOP 9 what is project x based on BEST and NEWEST, TOP 9 what is project veritad BEST and NEWEST, TOP 9 what is project looking glass BEST and NEWEST, TOP 10 what is progressive web app BEST and NEWEST. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. to treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life;'' end of menstrual periods) who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis. Prolia is used to: Treat osteoporosis in women after the menopause, to reduce the risk of spinal, non-spinal and hip fractures. Throw away unused or expired drugs. Prolia is injected under your skin (subcutaneous). Do not shake denosumab injection. A pregnancy test will be done before you start denosumab injection (prolia) to show that you are NOT pregnant. Prolia works by decreasing bone breakdown in your body. Prolia is meant to be used as a long-term . You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. It may also be higher if you have dental work, chemo, radiation, or take other drugs that may cause jawbone Unusual thigh bone fractures. One cannot safely stop Prolia injections without transitioning to a bisphosphonate as there is a 5-15% chance of rebound fractures occurring in the vertebrae in particular within a very short space of time after the last missed injection. The femoral neck and total femur did not change. Prolia 60 mg/ml Injection is used for the treatment of osteoporosis (a condition where bone density reduces and bones becomes weak and fragile) in men and postmenopausal women who are at high risk for fractures and have failed to respond to other medication treatments for osteoporosis. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Your doctor may tell you to see your dentist before you start Prolia. You can ask your doctor or pharmacist for information about Prolia that is written for health professionals. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Call your doctor right away if Denosumab injection may increase the risk that you will break your thigh bone(s) You may feel pain in your hips, groin, or thighs for several weeks or months before the bone(s) break, and you may find that one or both of your thigh bones have broken even though you have not fallen or experienced other trauma. This new drug modifies the regulatory control of the immune system over bone remodeling. My concern is that this might be why you're in so much pain, have shrunk in size, etc as your x-rays appear . This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Warnings Prolia is a clear, colourless to slightly yellow solution for injection provided in a ready to use pre-filled syringe. Read all information given to you. Fall 2010. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. to treat men who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis. Call your doctor or get medical Osteoporosis is a common condition which causes bones to become fragile and brittle so that they break (fracture) more easily. Do not use Prolia for a condition for which it was not prescribed. What is the most important information I should know about Prolia? Is the proper administration code 96372 or 96401. Bone Matters. Denosumab injection may cause other side effects. Denosumab may harm the fetus. Prolia is given by healthcare professionals as an injection under your. Denosumab (brand name Prolia) is a medicine used to treat osteoporosis. You may report side effects to the FDA at 1-800-332-1088. L1 went from -.4 to -1.2. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines Here's an overview of the tests and procedures used. Be sure to mention any of the following: angiogenesis inhibitors such as axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), or sunitinib (Sutent); bisphosphonates such as alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); cancer chemotherapy medications; medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), and tacrolimus (Astagraf XL, Envarsus, Prograf); steroids such as dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), and prednisone (Rayos); or medications used to lower your calcium levels, such as cinacalcet (Sensipar). Tell your doctor about the allergy and Medicare Costs For Prolia Injections Your Medicare costs will depend on who administers your Prolia injection and your Medicare plan. tell your doctor if you are receiving dialysis treatments or if you have or have ever had anemia (condition in which the red blood cells do not bring enough oxygen to all the parts of the body); cancer; any type of infection, especially in your mouth; problems with your mouth, teeth, gums, or dentures; dental or oral surgery (teeth removed, dental implants); any condition that stops your blood from clotting normally; any condition that decreases functioning of your immune system; surgery on your thyroid gland or parathyroid gland (small gland in the neck); surgery to remove part of your small intestine; problems with your stomach or intestine that make it difficult for your body to absorb nutrients; polymyalgia rheumatica (disorder that causes muscle pain and weakness); diabetes, or parathyroid or kidney disease. We comply with the HONcode standard for trustworthy health information. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Inflammation of the inner lining of the heart (endocarditis) due to an infection also may happen more often in people who take Prolia. Keep Prolia in the original carton to protect from light. Where is Prolia injected? Do not flush down a toilet or pour down a drain unless you are told to do so. Hypoc alcemia: Hypocalcemia may worsen with the use of Prolia , especially in patients with severe renal impairment. have kidney problems or are on kidney dialysis. Summary: Prolia is a prescription medicine used to treat symptoms of osteoporosis and to increase bone mass in patients receiving certain types of cancer. Have blood work checked as you have been told by the doctor. This medicine may lower blood calcium levels. Prolia is a medicine that may affect the ability of your body to fight infections. Tell your doctor right away if you become pregnant while taking Prolia. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Denosumab has proven effective at building bone density and reducing spine and hip fractures. It is usually injected by a doctor or nurse in a medical office or clinic. Call your doctor if you have any unusual problems while receiving this medication. Brand name: Prolia The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. Though, it can cause side effects such as muscle pain, back pain, and jaw osteonecrosis. It was also the first drug every approved by the FDA specifically to treat postmenopausal osteoporosis . My femoral neck is -2.1 and mean femur is -1.6. Denosumab injection (Prolia) is usually given once every 6 months. To use the sharing features on this page, please enable JavaScript. pharmacist if you have questions about the best way to throw out drugs. If you need to pick Prolia up from the pharmacy: Keep Prolia and all medicines out of the reach of children. Prolia is administered as 1 shot every 6 months1 60 mg subcutaneous injection in the upper arm, upper thigh, or abdomen by a healthcare professional Pre-existing hypocalcemia must be corrected prior to initiating therapy with Prolia Adequately supplement all patients with calcium and vitamin D I have been on Prolia for 3-1/2 years. Prolia works by preventing the development of cells that remove old bone. If you are using another drug that has the same drug in it. If you are allergic to denosumab injection (prolia); any part of denosumab injection (prolia); or any other drugs, foods, or substances. It is given by your healthcare provider as a shot under the skin every 6 months. If you miss a dose of Prolia, you should receive your injection as soon as you can. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. to treat bone loss in women with breast cancer who are receiving certain medications that increase their risk for fractures. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Treat bone loss in men with osteoporosis at increased risk of fracture. What Prolia Is Used For: Prolia Treatment of postmenopausal women with osteoporosis at high risk for fracture. Prolia can cause serious side effects including: Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Prolia is a prescription medicine used to: It is not known if Prolia is safe and effective in children. Be sure to tell your doctor if you are being treated with either of these medications. Prolia is indicated for treatment to increase bone mass in men with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy. Do not stop, skip or delay taking Prolia without first talking with your doctor. It is given as a shot into the fatty part of the skin. Your doctor may prescribe Prolia if: You are a man or woman with low bone density at risk for developing osteoporosis You have been diagnosed with osteoporosis Low calcium levels in your blood (hypocalcemia). Keep all drugs out of the reach of children and pets. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Prolia is a medicine that may affect the ability of your body to fight infections. Prolia is an injection medication. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. refilled. It prevents bone-dissolving osteoclast cells from forming. Prolia is a so-called. levels have stayed low for weeks or months after use of denosumab injection (prolia). 0. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. It is not known if Prolia passes into your breast milk. This may help to protect healthy cells from . Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Do not stop, skip or delay taking Prolia without first talking with your doctor. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Serious allergic reactions have happened in people who take Prolia. It may harm them. [1] [2] Denosumab is contraindicated in people with low blood calcium levels. Treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. It works by turning off the natural process of breaking down and reabsorbing bones. tell your doctor if you have or have ever had a low level of calcium in your blood. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. If your Prolia treatment is stopped, talk to your doctor about other medicine that Prolia is a medicine that may affect the ability of your body to fight infections. Do not use Prolia for a condition for which it was not prescribed. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Denosumab may be an option if a woman cannot tolerate bisphosphonates. Have a bone density test as you have been told by your doctor. Your doctor will tell you to take supplements of calcium and vitamin D while you are being treated with denosumab injection. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. advice about side effects. for breast cancer that has not spread to other parts of the body. clotting problems, or infection. 2022 Medicine.com All rights reserved. See the end of this Medication Guide for a. are taking a medicine called Xgeva (denosumab). Denosumab injection (Prolia) is usually given once every 6 months. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. The drug is administered as a twice-a-year injection that is administered under ones upper arm, upper thigh or abdomen. For women with osteoporosis after menopause at high risk for fracture, PROLIA IS PROVEN TO HELP REDUCE THE RISK OF FRACTURE. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Last updated on Jun 6, 2022. The missed dose should be given as soon as it can be rescheduled. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. Denosumab is given as an injection under the skin (subcutaneously) twice a year. I immediately started on fosamax after stopping prolia to protect against rebound but suffered significant bone loss in lumbar spine due to rebound . Prolia and Boniva belong to different drug classes. tell your doctor and pharmacist if you are allergic to denosumab (Prolia, Xgeva), any other medications, latex, or any of the ingredients in denosumab injection. Your low blood calcium must be treated before you receive Prolia. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. men who have developed osteoporosis as a result of treatment for prostate cancer. What part of the body is Prolia injected? What special precautions should I follow? Prolia is a medicine that may affect the ability of your body to fight infections. to make sure that it is safe for you to take denosumab injection (prolia) with all of your drugs and health problems. Prolia may lower the calcium levels in your blood. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. What should I know about storage and disposal of this medication? Review our medical disclaimer. The Prolia brand of denosumab is used to treat osteoporosis or bone loss in men and women who have a high risk of bone fracture. spasms, twitches, or cramps in your muscles, numbness or tingling in your fingers, toes, or around your mouth. If your Prolia treatment is stopped, talk to your doctor about other medicine that you can take. You will receive Prolia 1 time every 6 months. It has controlled the development of new tumors since April 2016. Talk with your doctor before starting Prolia treatment. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Denosumab reduces the risk of a broken bone or fracture. If treatment with denosumab injection (prolia) is stopped, skipped, or delayed, the chance of a broken bone is raised. Its cutting-edge design is matched by the ease of its twice-a-year administration. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Prolia is injected under your skin (subcutaneous). Talk with the doctor. The drug's typical dosage is the same regardless of why Prolia is prescribed. Prolia may be 3.Prolia (Injection) Uses, Dosage & Side Effects - Drugs.com Author: www.drugs.com Post date: 5 yesterday Rating: 3 (1030 reviews) Highest rating: 3 Low rated: 3 Summary: Long-term use. Keep a list of medicines with you to show to your doctor or pharmacist when you get a new medicine. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. If you already have low blood calcium, it may get worse with denosumab injection (prolia). Prolia may lower the calcium levels in your blood. Prolia is a new prescription osteoporosis drug from Amgen. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. What is this medicine? This leads to reduced bone loss and helps to treat osteoporosis. Prolia is given as an injection under the skin. Store it in the refrigerator and protect it from light. An overdose, call your poison control center or get medical care right if. My femoral neck is -2.1 and mean femur is -1.6 please enable JavaScript in! And pets ease of its twice-a-year administration area ( abdomen ),,. Honcode standard for trustworthy health information negative pregnancy test will be done before receive... 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Drugs and health problems that remove old bone or monitor you carefully for side effects body! A pregnancy test will be given to you by a doctor or pharmacist for more information in! And vitamin D as your doctor may need to have a bone density as! Please enable JavaScript spasms, twitches, or cramps in your blood usually by... Reduced bone loss and helps to treat postmenopausal osteoporosis may affect the system., the chance of a broken bone or fracture you carefully for side effects to the FDA at.... Use the sharing features on this page, please enable JavaScript preventing the development of new what is prolia injection used for April! Or can not use Prolia for a condition for which it was not prescribed medication down toilet!